Our Disease Focus

Heart failure is a devastating disease and pressing global healthcare concern

1 out of

4 individuals

…will develop heart
failure in their lifetime

70%

~70% of patients
hospitalized within a year

30%

Up to a third of patients
die within a year of initial hospitalization

Chronic, progressive disease of the cardiac muscle, limiting its ability to contract or relax and meet the body’s needs to pump blood to deliver oxygen and nutrients and remove toxic byproducts

High Hospitalization and Mortality Rates

Patients with heart failure can experience a continual decline in health…

Level of Functioning

… with very poor outcomes

Within a year of diagnosis: ~70% of patients are hospitalized; mortality rates as high as 30% 

Potential for continual disease progression and need for an artificial heart or heart transplant

No treatments address the root cause of failing heart muscle

Global Epidemic

64M+

Patients Globally 1

~7M

Patients in the US 2

Our initial focus is on non-ischemic dilated cardiomyopathy (DCM), a severe and progressive disease and leading cause of heart failure

Over 700,000 patients in the US are estimated to be living with non-ischemic DCM

References

Balmforth, C (2019), Kubanek, M (2013), Pecini, R (2011), Seferovic, P (2019)